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The Link Between Sleep Deprivation and Hormonal Imbalance

Medically Reviewed by Lucas Rosa, PhD in Biology

Sleep deprivation can wreak havoc on your hormonal balance and lead to numerous health issues.

The Science Behind Sleep and Hormones

Sleep is a critical time for our bodies. During sleep, the body undergoes many restorative processes, including the regulation of hormones. Hormones such as cortisol, melatonin, and growth hormone are particularly influenced by sleep.

Sleep is an important time when various hormones are released in our bodies. For example, during deep sleep, the body releases growth hormone, which is essential for tissue repair and muscle growth.

Melatonin and cortisol help regulate sleep-wake cycles and they follow a daily rhythm that can be disrupted by consistently having poor sleep.

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What Is Sleep Deprivation?

Sleep deprivation is when your body is not getting enough sleep. This could be not enough time sleeping or not enough good quality sleep.

Short-term sleep deprivation is usually not a problem, but long-term sleep deprivation can lead to many health issues and complications. 

Symptoms of sleep deprivation can include daytime sleepiness, fatigue, irritability, slowed reaction time, headaches, and a hard time focusing.

Ways To Counteract Insulin Resistance-2

Common Hormonal Imbalances Due Sleep Deprivation

Sleep deprivation can lead to a wide range of hormonal imbalances which can cause a variety of health challenges. The effects of being hormonally imbalanced can be seen after the first night of being sleep deprived, and it progressively worsens the longer you are sleep deprived.

These are the hormones that are commonly imbalanced due to a lack of sleep:

Insulin

Insulin helps regulate our blood sugar levels and sleep deprivation has a significant association with insulin resistance, which is when your body does not respond to insulin properly. This disruption can lead to high blood sugar levels and an increased risk of diabetes.

Hunger Hormones

Sleep deprivation can affect leptin and ghrelin, the hormones that regulate hunger and fullness after eating, leading to an increased risk of weight gain and obesity. A lack of sleep disturbs the balance of our hunger hormones causing us to feel hungrier during the day.

Thyroid Hormones

The thyroid regulates how the body uses energy. A lack of sleep can interfere with our thyroid hormones and affect metabolism, the process our body uses to turn the foods and drinks we consume into energy. This can lead to low energy levels, weight gain, and high blood pressure.

Growth Hormones

Our growth hormones are usually released when we sleep, so a lack of sleep will hinder the release of growth hormones which can lead to stunted height, decreased muscle mass, and weight gain. One night of sleep deprivation won’t stunt a person’s growth, but long periods of sleep deprivation can.

Cortisol

Cortisol is the body’s primary stress hormone, and it helps control the sleep-wake cycle by typically peaking early in the morning and declining throughout the day. However, sleep deprivation can cause elevated cortisol levels at inappropriate times which can lead to chronic stress and increased anxiety.

Melatonin

Melatonin helps regulate our circadian rhythm which is our body’s natural 24-hour clock. This rhythm helps our body stay on a healthy sleep-wake cycle, and sleep deprivation disrupts this rhythm leading to a lack of energy, digestion issues, and a weakened immune system.

Sex Hormones

Sleep deprivation can significantly influence our sex hormones which help regulate fertility and reproduction.

In those assigned female at birth, sleep deprivation can disrupt estrogen levels, leading to menstrual disruptions and fertility issues.

In those assigned male at birth, a lack of sleep can lower testosterone levels, affecting libido and overall reproductive health.

Both men and women may experience reduced sexual satisfaction and intimacy issues as a result of hormonal imbalances caused by poor sleep.

Possible Health Effects of Insulin Imbalance (8)-1

Tips to Improve Sleep

Having good sleep is essential for hormonal balance, and there are practical steps you can take towards improving both sleep and hormone health. 

Here are some tips to help you improve your sleep:

  • Have a consistent sleep schedule
  • Create a relaxing bedtime routine
  • Reduce exposure to screens before bed
  • Healthily manage stress
  • Exercise regularly
  • Make a comfortable sleep environment
  • Avoid heavy meals close to bedtime
  • Avoid highly emotional activities before bed
  • Listen to calming music
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Conclusion

Sleep is essential for hormonal balance and overall health. Chronic sleep deprivation can lead to various hormonal imbalances, affecting everything from stress levels to reproductive health.

By prioritizing good sleep habits and taking practical steps to improve sleep quality, you can help restore hormonal balance and promote long-term wellbeing.


Sources:

Better Health Channel. “Sleep Deprivation.” Better Health Channel, 30 June 2014, www.betterhealth.vic.gov.au/health/conditionsandtreatments/sleep-deprivation

Cleveland Clinic. “Sleep Deprivation: What It Is, Symptoms, Treatment & Stages.” Cleveland Clinic, 11 Aug. 2022, https://my.clevelandclinic.org/health/diseases/23970-sleep-deprivation

Cleveland Clinic. “What Is Circadian Rhythm?” Cleveland Clinic, 15 Mar. 2024, https://my.clevelandclinic.org/health/articles/circadian-rhythm.  

Colten, Harvey R, and Bruce M Altevogt. “Extent and Health Consequences of Chronic Sleep Loss and Sleep Disorders.” National Institute of Health, National Academies Press (US), 2019, www.ncbi.nlm.nih.gov/books/NBK19961/

Dowshen, Steven. “Can Lack of Sleep Stunt Your Growth? (for Teens) – KidsHealth.” KidsHealth, 2017, www.kidshealth.org/en/teens/sleep-growth.html

Finan, Patrick. “The Effects of Sleep Deprivation.” Johns Hopkins Medicine, 2019, www.hopkinsmedicine.org/health/wellness-and-prevention/the-effects-of-sleep-deprivation

Kim, Tae Won, et al. “The Impact of Sleep and Circadian Disturbance on Hormones and Metabolism.” International Journal of Endocrinology, vol. 2015, no. 591729, 2015, pp. 1–9, www.ncbi.nlm.nih.gov/pmc/articles/PMC4377487/, https://doi.org/10.1155/2015/591729

Pacheco, Danielle. “Could Your Thyroid Be Causing Sleep Problems?” Sleep Foundation, 8 Mar. 2024, www.sleepfoundation.org/physical-health/thyroid-issues-and-sleep

Pacheco, Danielle, and David Rosen. “Bedtime Routines for Adults.” Sleep Foundation, 8 Dec. 2023, www.sleepfoundation.org/sleep-hygiene/bedtime-routine-for-adults

Pacheco, Danielle, and Abhinav Singh. “How a Lack of Sleep May Increase Calorie Consumption.” Sleep Foundation, 11 Dec. 2020, www.sleepfoundation.org/sleep-deprivation/lack-sleep-may-increase-calorie-consumption

Singh, Trisha, et al. “Does Insufficient Sleep Increase the Risk of Developing Insulin Resistance: A Systematic Review.” Cureus, 26 Mar. 2022, https://pmc.ncbi.nlm.nih.gov/articles/PMC9036496/#sec3, https://doi.org/10.7759/cureus.23501

Stachel, Jordan. “Melatonin Deficiency: Common Symptoms & Causes | Everlywell.” Everlywell, 2019, www.everlywell.com/blog/sleep-and-stress/what-is-melatonin-deficiency/?srsltid=AfmBOopdU_yd4PxkMtmJdY3O_-_HwwTgYYdGcpGWdEE_-SnOUwitJanz

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